RETIRED WITH HONORS · seansooch.dev Vol. 03, five views (Claude Fable 5.1, OpenAI Astra, Claude Opus 5.5, Cursor Composer 2.5, Grok 4.7; September to November 2026) · frozen 2026-11-09 · Current edition by Claude Fable 5.2 →
SS03

Medicine, one step at a time · since October 2026

The Lab

A course in core medicine, taught one picture at a time. Each lesson takes a single idea, starting with how the heart fills and empties, builds it step by step in plain language with animated visuals, then shows how disease and common drug classes change the picture. New lessons are added in order.

Every lesson has a Clinical values tab: typical adult reference ranges from standard physiology textbooks and major guidelines, each one cited, drawn against the lesson as it runs. The lessons are educational only and not for clinical use; they give no drug doses. Everything runs in your browser, with no accounts and no trackers, and works on a phone and with a keyboard.

22 of 22 lessons readyLatest: Nov 7, 2026

  1. The Pressure–Volume Loop

    How one heartbeat fills and empties the left ventricle, drawn as a loop, and how fluids, blood pressure and heart drugs reshape it.

    Lesson 1 · IV fluids (more preload), Arterial vasoconstrictors and hypertension (more afterload), Positive inotropes, Venodilators, Beta-blockers, Heart failure with reduced ejection fraction

  2. The Nephron and Diuretics

    Follow salt and water along a nephron, segment by segment, and see where each diuretic blocks salt reabsorption and how much water follows it out.

    Lesson 2 · Loop diuretics (furosemide), Thiazide diuretics, Potassium-sparing diuretics (aldosterone antagonists, ENaC blockers), Carbonic anhydrase inhibitors (acetazolamide), Osmotic diuretics (mannitol)

  3. Frank–Starling and Cardiac Output

    Why a fuller heart pumps harder, and how filling, heart rate and contraction strength add up to cardiac output.

    Lesson 3 · IV fluids, Diuretics (less preload), Positive inotropes, Beta-blockers, Venodilators (nitrates), Heart failure

  4. Blood Pressure Regulation

    Blood pressure as flow times resistance, and how the baroreflex keeps it steady from one moment to the next.

    Lesson 4 · Calcium channel blockers, Alpha-1 blockers, Central alpha-2 agonists, Beta-blockers, Direct vasodilators, Hemorrhage (volume loss)

  5. The Renin–Angiotensin–Aldosterone System

    The hormone chain the kidney uses to raise blood pressure and hold on to salt, and the drugs that cut it at each link.

    Lesson 5 · ACE inhibitors, Angiotensin receptor blockers (ARBs), Aldosterone antagonists (spironolactone), Direct renin inhibitors

  6. The Autonomic Synapse

    How sympathetic and parasympathetic nerves talk to organs through receptors, and how drugs mimic or block that signal.

    Lesson 6 · Muscarinic agonists and antagonists, Cholinesterase inhibitors, Alpha agonists and blockers, Beta agonists and blockers

  7. The Cardiac Action Potential

    The ion currents behind each heartbeat, in pacemaker and muscle cells, and how antiarrhythmic drugs change their shape.

    Lesson 7 · Sodium channel blockers (class I), Beta-blockers (class II), Potassium channel blockers (class III), Calcium channel blockers (class IV)

  8. The Neuromuscular Junction

    How a nerve signal becomes a muscle contraction, and how paralytic and reversal drugs act at the junction.

    Lesson 8 · Nondepolarizing neuromuscular blockers, Depolarizing neuromuscular blockers (succinylcholine), Cholinesterase inhibitors (reversal), Myasthenia gravis

  9. Oxygen and Hemoglobin

    Why hemoglobin grabs oxygen in the lungs and lets go in the tissues, drawn as the dissociation curve, and what shifts it.

    Lesson 9 · Right shift (acid, carbon dioxide, heat, 2,3-BPG), Left shift (fetal hemoglobin, cold, alkalosis), Carbon monoxide poisoning, Anemia

  10. Ventilation, Perfusion and the Alveolus

    How air and blood meet in the lung, and what happens to oxygen when the two are mismatched.

    Lesson 10 · Supplemental oxygen, Bronchodilators (beta-2 agonists, muscarinic antagonists), Pulmonary embolism (dead space), Pneumonia (shunt)

  11. Acid–Base Balance

    The bicarbonate buffer, the lungs and the kidneys working together to hold blood pH steady, and the four ways it goes wrong.

    Lesson 11 · Carbonic anhydrase inhibitors, Loop and thiazide diuretics (contraction alkalosis), Sodium bicarbonate, Salicylate toxicity

  12. The Coagulation Cascade

    How a clot is built, from platelet plug to fibrin mesh, and where each anticoagulant and clot-busting drug acts.

    Lesson 12 · Heparins, Vitamin K antagonists (warfarin), Factor Xa inhibitors, Direct thrombin inhibitors, Antiplatelet drugs, Thrombolytics

  13. Insulin and Glucose

    How insulin moves glucose out of the blood after a meal, what fails in diabetes, and how each diabetes drug helps.

    Lesson 13 · Insulin, Metformin, Sulfonylureas, SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors

  14. The Thyroid Axis

    The brain-to-thyroid feedback loop that sets the body's metabolic pace, and the drugs that replace or suppress thyroid hormone.

    Lesson 14 · Levothyroxine, Thionamides (methimazole, propylthiouracil), Radioactive iodine, Beta-blockers for symptoms

  15. The HPA Axis and Steroids

    How the brain and adrenal glands control cortisol through feedback, and why steroid drugs switch the axis off.

    Lesson 15 · Glucocorticoids, Mineralocorticoids, Steroid synthesis inhibitors, Cushing syndrome and adrenal insufficiency

  16. Stomach Acid and the Parietal Cell

    How one stomach cell pumps acid on command, and how acid-reducing drugs turn it down at different steps.

    Lesson 16 · Proton pump inhibitors, H2 receptor blockers, Antacids, Prostaglandin analogues

  17. Pharmacokinetics: Drug Levels Over Time

    How a drug's level rises, plateaus and falls in the blood: absorption, distribution, half-life and steady state, drawn as curves.

    Lesson 17 · Enzyme inducers, Enzyme inhibitors, Reduced kidney clearance, Oral versus intravenous routes

  18. Inflammation and the Arachidonic Acid Pathway

    How injured cells make prostaglandins and leukotrienes, and where anti-inflammatory drugs block the pathway.

    Lesson 18 · NSAIDs, COX-2 selective inhibitors, Aspirin, Glucocorticoids, Leukotriene modifiers

  19. The Bacterial Cell and Antibiotic Targets

    A tour of a bacterium's wall, ribosomes and DNA machinery, and the antibiotic families that attack each one.

    Lesson 19 · Beta-lactams, Glycopeptides (vancomycin), Aminoglycosides, Macrolides and tetracyclines, Fluoroquinolones, Sulfonamides and trimethoprim

  20. The Immune Response

    How the body recognises an invader, from the first innate response to antibodies and memory, and how immune drugs steer it.

    Lesson 20 · Vaccines, Calcineurin inhibitors, Anti-TNF biologics, Glucocorticoids

  21. The Cell Cycle and Chemotherapy

    How a cell copies itself, phase by phase, and which chemotherapy drugs strike at which phase.

    Lesson 21 · Antimetabolites (S phase), Vinca alkaloids and taxanes (M phase), Alkylating agents, Topoisomerase inhibitors, CDK4/6 inhibitors

  22. ADH and Water Balance

    Watch the brain sense blood saltiness, release ADH and open water channels in the kidney, then see urine change in DI, SIADH and polydipsia.